Multimodal foundation models hold significant potential for automating radiology report generation, thereby assisting clinicians in diagnosing cardiac diseases. However, generated reports often suffer from serious factual inaccuracy. In this paper, we introduce a fact-aware multimodal retrieval-augmented pipeline in generating accurate radiology reports (FactMM-RAG). We first leverage RadGraph to mine factual report pairs, then integrate factual knowledge to train a universal multimodal retriever. Given a radiology image, our retriever can identify high-quality reference reports to augment multimodal foundation models, thus enhancing the factual completeness and correctness of report generation. Experiments on two benchmark datasets show that our multimodal retriever outperforms state-of-the-art retrievers on both language generation and radiology-specific metrics, up to 6.5% and 2% score in F1CheXbert and F1RadGraph. Further analysis indicates that employing our factually-informed training strategy imposes an effective supervision signal, without relying on explicit diagnostic label guidance, and successfully propagates fact-aware capabilities from the multimodal retriever to the multimodal foundation model in radiology report generation.

Objective For the UK Biobank standardized phenotype codes are associated with patients who have been hospitalized but are missing for many patients who have been treated exclusively in an outpatient setting. We describe a method for phenotype recognition that imputes phenotype codes for all UK Biobank participants. Materials and Methods POPDx (Population-based Objective Phenotyping by Deep Extrapolation) is a bilinear machine learning framework for simultaneously estimating the probabilities of 1,538 phenotype codes. We extracted phenotypic and health-related information of 392,246 individuals from the UK Biobank for POPDx development and evaluation. A total of 12,803 ICD-10 diagnosis codes of the patients were converted to 1,538 Phecodes as gold standard labels. The POPDx framework was evaluated and compared to other available methods on automated multi-phenotype recognition. Results POPDx can predict phenotypes that are rare or even unobserved in training. We demonstrate substantial improvement of automated multi-phenotype recognition across 22 disease categories, and its application in identifying key epidemiological features associated with each phenotype. Conclusions POPDx helps provide well-defined cohorts for downstream studies. It is a general purpose method that can be applied to other biobanks with diverse but incomplete data.

Applying machine learning in the health care domain has shown promising results in recent years. Interpretable outputs from learning algorithms are desirable for decision making by health care personnel. In this work, we explore the possibility of utilizing causal relationships to refine diagnostic prediction. We focus on the task of diagnostic prediction using discomfort drawings, and explore two ways to employ causal identification to improve the diagnostic results. Firstly, we use causal identification to infer the causal relationships among diagnostic labels which, by itself, provides interpretable results to aid the decision making and training of health care personnel. Secondly, we suggest a post-processing approach where the inferred causal relationships are used to refine the prediction accuracy of a multi-view probabilistic model. Experimental results show firstly that causal identification is capable of detecting the causal relationships among diagnostic labels correctly, and secondly that there is potential for improving pain diagnostics prediction accuracy using the causal relationships.